Margatoxin
Kv1.3 selective blocker
如果您對該產品感興趣的話,可以
產品名稱: Margatoxin
Kv1.3 selective blocker
產品型號: 08MAG001-00100
產品展商: 其他品牌
產品文檔: 無相關文檔
簡單介紹
Margatoxin
Kv1.3 selective blocker
的詳細介紹
Margatoxin
Kv1.3 selective blocker
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 μM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.
